Description
Interleukin-15 (IL-15) is a widely expressed cytokine that shares structural and functional similarities with IL-2, and it plays a critical role in various immune diseases[1]. IL-15 binds with high affinity to its receptor, IL-15Rα, which is co-expressed on the cell surface[2-3]. It induces or enhances the differentiation, maintenance, and activation of diverse T cell subsets, including natural killer (NK) cells, natural killer T (NKT) cells, Th17 cells, regulatory T (Treg) cells, and CD8+ memory T cells. In stem
cell culture protocols, IL-15 can be utilized in conjunction with other cytokines, such as IL-21, to enhance the efficiency of NK cell expansion and maturation[4].
Product Information
Expressed system: CHO
Molecular weight: 12.7 kDa
Purity: > 95% by SEC-HPLC, SDS-PAGE analysis.
Endotoxin: < 10 EU/mg
Biological activity: Measured in a cell proliferation assay using CTLL-2, ED50 between 1-5 ng/ml.
Form: lyophilized, sterile
Storage
at -20°C for two years.
Shipping
Dry ice (-70℃)
[1] Di Sabatino A, Calarota SA, Vidali F, MacDonald TT, Corazza GR. Role of IL-15 in immune-mediated and infectious diseases. Cytokine Growth Factor Rev, 2011, 22:19-33.
[2] Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, Shanebeck K, et al. Identification and cloning of a novel IL-15 binding-protein that is structurally related to the alpha-chain of the Il-2 receptor. EMBO J, 1995, 14(15):3654-63.
[3] Dubois S, Mariner J, Waldmann TA, and Tagaya Y. IL-15 Ralpha recycles and presents IL-15 In trans to neighboring cells. Immunity, 2002, 17:537-547.
[4] Oberoi P, Kamenjarin K, Ossa JFV, Uherek B, Bönig H, and Wels WS. Directed Differentiation of Mobilized Hematopoietic Stem and Progenitor Cells into Functional NK cells with Enhanced Antitumor Activity. Cells, 2020, 9:811.
Reviews
There are no reviews yet.