Description
Histone H3 is an important component of the nucleosome, which, along with H2A, H2B, and H4, forms a heteroctamer around which the DNA tightly wraps to form a nucleosome[1]. Histone H3 plays an important role in cell proliferation, transcription regulation, DNA repair and replication, chromosomal stability, etc. A variety of post-translational modifications of Histone H3 bring about changes in function[2], phosphorylation of Histone H3 at Ser10[3] and Ser28[4] regulates chromosome condensation during mitosis, Histone H3 at Lys4, Lys9, and Lys14 can be methylated by histone methyltransferases, thereby affecting DNA transcription[5][6].
Storage
PBS (pH 7.4), 0.02% Sodium Azide, 50% Glycerol;
at -20℃ for two years, avoid repeated freeze-thawing.
Shipping
Dry ice (-70℃)
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