Description
Basic Fibroblast Growth Factor (FGF-basic), also known as bFGF or FGF2, is a member of the fibroblast growth factor family. As a ligand for FGFR1, FGFR2, FGFR3, and FGFR4, bFGF plays a critical role in regulating cell survival, proliferation, differentiation, and migration[1]. FGF-basic is an essential component of human embryonic stem cell (hESC) culture media, required for maintaining cells in an undifferentiated state. When combined with BMP4, it promotes the differentiation of embryonic stem cells into mesodermal lineages[2]. In both in vivo and in vitro settings, bFGF demonstrates potent angiogenic activity, stimulates smooth muscle cell growth, and enhances wound healing and tissue regeneration[3].
This product is a sequence-optimized human FGF-basic, produced in a prokaryotic expression system through fermentation and highly purified. It exhibits enhanced chemical stability and high biological activity, making it suitable for the culture of various primary cells and stem cells.
Storage
at -18˚C or below for two years
Shipping
Dry ice (-70℃)
| Component | PM104-01 | PM104-02 | PM104-03 |
| Recombinant Human FGF Basic Protein (GMP Grade) | 10 μg | 50 μg | 1 mg |
[1] Farooq M, Khan AW, Kim MS, Choi S: The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration. Cells, 2021, 10(11):3242.
[2] Pereira LV, Lotz S, Goderie S, Tokas N, Hirsch SE, Ahmad F, Corneo B, Le S, Banerjee A, Kane RS et al: Sustained Levels of FGF2 Maintain Undifferentiated Stem Cell Cultures with Biweekly Feeding. PLoS ONE, 2013, 8(2):e56289.
[3] Prudovsky I: Cellular Mechanisms of FGF-Stimulated Tissue Repair. Cells, 2021, 10(7):1830.
Reviews
There are no reviews yet.